What is an anxiety attack? Symptoms, how long it lasts, and what to do
"Anxiety attack" isn't a diagnosis, but the symptoms are real. Here's what research says about panic attacks, how long they last, and what helps.

Short answer
An anxiety attack is an everyday name, not a diagnosis, for a sudden surge of intense fear with a pounding heart, breathlessness, dizziness or trembling. Usually it means a panic attack, which peaks within minutes. About 13% of adults in 25 countries have had one. It isn't life-threatening, but new chest pain always needs emergency care.
If you've had one, you're not imagining it, and it's not weakness. The symptoms are real. Your heart really does race, your breathing really does change, and the fear of dying or "going crazy" is one of the textbook symptoms, not a sign that you are overreacting. It is your body's alarm system firing at full volume when there is no danger to answer.
This article explains what people usually mean by "anxiety attack," what one feels like, how long it lasts, what tends to trigger it, what to do during one (and what the evidence actually supports), when attacks point to panic disorder or generalized anxiety disorder, how they are treated, and which symptoms should never be written off as "just anxiety."
What is an anxiety attack, exactly?
"Anxiety attack" is a phrase people use every day, but you won't find it in the diagnostic manuals doctors use. The US manual, the DSM-5-TR, defines a panic attack instead: an abrupt surge of intense fear or discomfort that reaches its peak within minutes, with at least 4 of 13 listed symptoms (doi.org). A panic attack can start from a calm state or from an already anxious one.
When people say "anxiety attack," they usually mean one of two things:
A panic attack. A sudden, intense wave that comes on fast, peaks quickly and then fades. This is the most common meaning, and it is the one with clear research behind it.
A build-up of anxiety. Worry that climbs over hours in response to a stressor — an exam, a medical result, a fight — with a tight chest, racing thoughts, restlessness and trouble settling. It is usually less explosive than a panic attack but can last longer.
The two often blur together in real life, and both deserve to be taken seriously. It also helps to separate a few words that get mixed up:
| Term | What it means | Key feature |
|---|---|---|
| Fear | Response to a real, present threat | Happening now; fight-or-flight fires in the moment |
| Anxiety | Anticipation of a future or uncertain threat | Worry about what might happen; can persist without a clear trigger |
| Anxiety attack | Everyday term for a sudden, intense wave of fear with body symptoms | Usually means a panic attack; not a formal diagnosis |
| Anxiety disorder | Anxiety that is excessive, hard to control and disrupts daily life | A clinical diagnosis made against defined criteria |
Fear and anxiety are both normal in the right dose. Fear helps you react; anxiety can help you plan. The trouble starts when the alarm is too loud, goes off too often, or fires when nothing in front of you matches its intensity. We unpack that line in more detail in anxiety vs. an anxiety disorder.
Anxiety attack vs. panic attack: what's the difference?
The short version: "panic attack" is the clinical term, and "anxiety attack" is the everyday one. Most of the time they describe the same experience.
Where people do draw a line, it usually looks like this. A panic attack is sudden, peaks within minutes and can come "out of the blue." What people call an anxiety attack more often builds gradually, is tied to a specific worry, and feels more like a long, rising tension than an explosion. The symptoms overlap — racing heart, tight chest, shaky hands — but panic tends to be more intense and shorter.
We compare the two symptom by symptom, including how to tell which one you had, in panic attack vs. anxiety attack. The rest of this article focuses on what the research says about the experience itself, and most of that research is on panic attacks.
What does an anxiety attack feel like?
People describe it as a wave that hits all at once: the heart suddenly pounds, breathing gets fast and shallow, the chest tightens, and a powerful sense of danger arrives with no clear reason. Many people are convinced they are having a heart attack, fainting, or losing their mind.
The DSM-5-TR lists 13 possible symptoms of a panic attack (doi.org):
Pounding heart, palpitations or a racing heart rate
Sweating
Trembling or shaking
Feeling short of breath or smothered
A choking feeling
Chest pain or discomfort
Nausea or stomach distress
Feeling dizzy, unsteady, light-headed or faint
Chills or waves of heat
Numbness or tingling, often in the hands, feet or around the mouth
Feeling detached from yourself or that the world around you isn't real (called depersonalization and derealization)
Fear of losing control or "going crazy"
Fear of dying
A full panic attack involves four or more of these. Episodes with fewer than four are sometimes called limited-symptom attacks, and they can still be very unpleasant. The US National Institute of Mental Health (NIMH) notes that the physical symptoms can feel like a heart attack and that attacks can happen at any time, even during sleep (NIMH).
Breathlessness is one of the most frightening parts for many people, and it has its own explanations and fixes; see shortness of breath from anxiety. For a wider list of how panic and anxiety show up in the body, including less obvious signs, see panic symptoms and anxiety symptoms.
What happens in your body during an anxiety attack
An anxiety attack is not "just in your head." Your brain and body run the same threat-response loop. When that system senses danger — real, uncertain or imagined — the autonomic nervous system shifts into fight-or-flight. Heart rate rises, breathing speeds up, muscles tighten, digestion slows, and attention narrows onto the threat.
Breathing plays a surprisingly large role. When you breathe fast, you blow off carbon dioxide faster than your body makes it. Low carbon dioxide can cause tingling fingers, light-headedness and a feeling of not getting enough air — which makes you breathe even faster. In a study that recorded 13 real panic attacks in people with panic disorder during 1,960 hours of 24-hour monitoring, the start of an attack was marked by a jump in heart rate, deeper breaths and a drop in carbon dioxide (doi.org).
Psychologists describe the rest as a vicious cycle. You notice a body sensation (a skipped beat, a wave of dizziness), you read it as a sign of catastrophe ("I'm having a heart attack"), the fear releases more adrenaline, the sensations get stronger, and they seem to confirm the fear (doi.org). NIMH describes panic attacks in similar terms, as "false alarms" of the body's survival instincts (NIMH). That cycle is exactly what modern treatment targets, which is why understanding it helps.
A large genetic study of anxiety disorders described them as, probably, "differential expressions of a dysregulated threat-response system" (doi.org). The body side is measurable, too. In a meta-analysis of 36 studies comparing 2,086 people with anxiety disorders with 2,294 people without, those with anxiety disorders had lower heart rate variability (HRV) at rest — a sign that the calming, "rest-and-digest" branch of the nervous system is less active. The effect was small to moderate, and it was seen in panic disorder, generalized anxiety disorder and others (doi.org). That is an average across groups, not a test: your HRV can't tell you or anyone else whether you have an anxiety disorder.
One caution from the other side. A racing heart, or a big jump in heart rate when you stand up, is not always anxiety. It can point to heart rhythm problems or conditions like POTS (postural orthostatic tachycardia syndrome), where the trigger is physical. A fast heartbeat caused by a heart problem is often wrongly blamed on anxiety. Your body can show a pattern; a clinician is the one who can tell you what it means.
How long do anxiety attacks last?
Most panic attacks are short. By definition, they peak within minutes (doi.org). NIMH says a panic attack can last from a few minutes to an hour or sometimes longer, and that the physical symptoms usually resolve with time (NIMH).
A few things make an attack feel longer than it is:
The aftermath. Once the peak passes, many people feel shaky, drained or on edge for a while. That hangover is not the attack continuing; it's the body coming down from a big surge of adrenaline.
Back-to-back waves. Fear of the next wave can set off another one, so a single "attack" may really be several in a row.
The build-up. Attacks that feel sudden may not be. In the monitoring study above, patterns of instability in breathing, heart rate and sweating showed up as early as 47 minutes before attacks that people reported as abrupt and unexpected (doi.org). That was a small study, but it suggests the body often starts revving before the mind notices.
The slower, worry-driven kind of anxiety episode can last longer — sometimes hours — because it rises and falls with the thing you are worried about.
Some attacks happen at night. Waking from sleep in a state of panic is common in panic disorder: 44–71% of patients report at least one such attack. These nocturnal panic attacks come out of non-REM sleep and are different from nightmares, night terrors or sleep apnea (doi.org). If this sounds familiar, read anxious at night for no reason and heart racing at night.
If symptoms last much longer than usual, don't ease off, or feel different from your typical attacks, don't assume it's anxiety — get checked.
Can an anxiety attack kill you?
A panic attack on its own is not dangerous. NIMH states plainly that panic attacks themselves are not life-threatening (NIMH). The fear of dying is a symptom of the attack, not a prediction. Tingling, dizziness and air hunger from fast breathing feel alarming but pass as your breathing settles.
There are three important caveats.
First, you can't always tell an anxiety attack from a heart problem, and neither can doctors without testing. In a Montreal emergency department that specializes in cardiac care, about 25% of 441 consecutive patients with chest pain met criteria for panic disorder. Of those, 44% also had a documented history of coronary artery disease — so panic and heart disease often coexist. And 98% of the panic cases weren't recognized by the attending cardiologists (doi.org). The lesson cuts both ways: chest pain deserves a proper workup, and a normal heart test doesn't mean your symptoms are imaginary.
Second, some heart rhythm problems look exactly like panic. In 107 patients with a common rhythm problem called paroxysmal supraventricular tachycardia (PSVT), 67% met the criteria for panic disorder. The rhythm problem went unrecognized at first in 55% of them, for a median of 3.3 years, and doctors attributed symptoms to panic, anxiety or stress in 54% of those missed cases. Women were more likely than men to be told it was psychological (65% vs. 32%) (doi.org). If your "attacks" start and stop like a switch, or your heart rate is extremely fast, ask about a heart rhythm monitor.
Third, long-term, panic disorder is linked to heart disease. In a meta-analysis of 12 studies covering more than 1.1 million people, panic disorder was associated with about 1.47 times the risk of later coronary heart disease, after adjusting for other factors. The authors couldn't rule out reverse causality — early, undiagnosed heart problems might cause panic-like symptoms rather than the other way around (doi.org). That's a reason to treat panic disorder and look after your heart, not a reason to fear each attack.
One old remedy is worth dropping: breathing into a paper bag. An emergency physician reported three deaths when paper-bag rebreathing was used on people who were thought to be hyperventilating from anxiety but actually had low oxygen or a heart attack. In healthy volunteers, rebreathing dropped oxygen levels substantially within minutes (doi.org).
What causes anxiety attacks?
There is rarely a single cause. Anxiety attacks usually come from a sensitive alarm system meeting the right mix of triggers.
Genes and temperament. Panic disorder runs in families. A meta-analysis of twin and family studies estimated its heritability at 0.43, meaning genes explain a large share of who is at risk, with the rest mostly coming from each person's individual experiences (doi.org). A 2026 genome-wide study of 122,341 people with anxiety disorders found 58 genetic risk variants and strong genetic overlap with depression and neuroticism (doi.org). None of this means your fate is sealed; it means some alarms are built to be more sensitive.
Fear of the sensations themselves. People who read normal body sensations as dangerous are more likely to spiral into panic (doi.org). After a first attack, many people start scanning their bodies for signs of the next one, which makes the next one more likely.
Stress. Hard stretches — a loss, a move, a demanding job, illness — lower the threshold. NIMH notes researchers are studying how stress and environmental factors feed into panic disorder (NIMH).
Short sleep. In research from the University of California, Berkeley, a night without sleep raised next-day anxiety, and even modest night-to-night reductions in sleep across a larger group predicted higher anxiety the next day (doi.org).
Caffeine. A systematic review found eight randomized, double-blind studies in which caffeine was given to people with panic disorder; all eight showed a link between caffeine and anxiety or panic effects (doi.org). The studies were small and had high dropout, but if you're prone to attacks, it is a reasonable thing to cut back on.
Substances and medical causes. Alcohol or drug withdrawal, stimulants, some medications and medical conditions such as an overactive thyroid or heart rhythm problems can produce panic-like symptoms. The diagnostic manual asks clinicians to rule these out before calling it a panic attack or disorder (doi.org).
For a deeper look at triggers and how to spot your own, see what causes anxiety attacks.
How to stop an anxiety attack: what to do during one
There is no switch that ends an attack instantly. But you can shorten the spiral and stop feeding it. Here is a step-by-step approach, with an honest note on how strong the evidence is for each part.
1. Name it. Tell yourself: "This is a panic attack. It peaks and it passes. It is not dangerous." This isn't wishful thinking. Breaking the link between a sensation and a catastrophic meaning is the core of cognitive behavioral therapy (CBT), the best-studied treatment for panic (doi.org) (doi.org). Only do this if you've already had your symptoms checked — a first episode of chest pain needs medical care, not self-talk.
2. Slow your breathing, with a longer breath out. Try breathing in through your nose for about 4 seconds and out slowly for about 6, keeping it gentle rather than deep. A systematic review of slow breathing (under 10 breaths a minute) found it increased HRV and was linked to more relaxation and less anxiety and arousal in healthy people (doi.org). In a one-month randomized study, five minutes a day of "cyclic sighing" — a double inhale followed by a long exhale — improved mood and lowered breathing rate more than mindfulness meditation did (doi.org). A meta-analysis of randomized trials found breathwork was associated with small-to-moderate reductions in anxiety (g = −0.32 across 20 trials), while urging caution about hype (doi.org).
The honest part: most of these studies were in healthy people or measured everyday stress, not the middle of a panic attack. In a trial of 77 people with panic disorder, adding breathing retraining to CBT gave no extra benefit, and some data hinted at a slightly worse outcome (doi.org). A newer approach that trains people to breathe more slowly and shallowly using carbon dioxide feedback helped in a small trial of 37 patients (doi.org). So slow breathing is a useful, low-risk tool — just don't treat it as something you must get "right" to be safe.
3. Ground your attention. Look around and name five things you can see, four you can feel, three you can hear, two you can smell and one you can taste. Or press your feet into the floor and describe the room to yourself in detail. There are no good trials of grounding for panic attacks specifically. It's recommended because it's harmless and pulls attention away from body-scanning, which feeds the cycle.
4. Let it peak rather than fighting or fleeing. It's natural to want to run out of the room. But escaping teaches your brain the situation was dangerous. CBT uses exposure — including deliberately bringing on harmless sensations like a fast heartbeat, called interoceptive exposure — to teach the opposite: the sensations rise, peak and fall on their own (NIMH). If you can, stay where you are and let the wave pass.
5. Relax your muscles. Drop your shoulders, unclench your jaw and hands, and let your belly soften. Applied relaxation, a structured version of this skill, is one of the therapies the UK's NICE guideline offers for generalized anxiety disorder (NICE).
6. Afterwards, be kind to yourself. Rest, drink some water, and skip the coffee for a while. Jot down when it happened, what came before it, and how long the peak lasted. Patterns you notice over weeks — poor sleep, a stressful day, a strong coffee — are valuable to you and your clinician.
If you're helping someone else, stay calm and close, speak slowly, and remind them it will pass. Breathe slowly with them rather than telling them to "calm down." Don't hand them a paper bag. If they have chest pain, trouble breathing that isn't easing, or this is a first episode, call emergency services.
When is it panic disorder or generalized anxiety disorder?
One panic attack doesn't mean you have a disorder. In a US survey of 9,282 adults, 22.7% had experienced panic attacks at some point without developing panic disorder or agoraphobia; 3.7% had panic disorder without agoraphobia and 1.1% had panic disorder with it (doi.org). Across 25 countries and 142,949 adults, 13.2% had had at least one panic attack, and only 12.8% of those went on to meet criteria for panic disorder (doi.org).
Panic disorder is diagnosed when panic attacks are recurrent and unexpected, and at least one is followed by a month or more of persistent worry about more attacks or what they mean, or by changes in behavior to avoid them (doi.org). Many people start avoiding places where attacks happened, like supermarkets, public transport or driving. When that avoidance grows, it's called agoraphobia. The same cross-national survey found that repeated panic attacks — even without panic disorder — were linked to about twice the odds of later developing other mental health conditions, while a single attack was not (doi.org). That makes recurring attacks worth treating early.
Generalized anxiety disorder (GAD) looks different. Instead of sudden peaks, it's excessive, hard-to-control worry about many things — health, money, work, family — on more days than not for at least six months, with symptoms like restlessness, tiredness, poor concentration, irritability, muscle tension and poor sleep (doi.org). People with GAD can also have panic attacks. Our guide to generalized anxiety disorder covers it in depth.
Anxiety disorders are a family of related conditions. In the US, 18.1% of adults meet criteria for at least one in a given year (doi.org).
Panic disorder — Recurrent, unexpected panic attacks plus ongoing fear of the next one or avoidance
Generalized anxiety disorder — Persistent, excessive worry across many areas with body symptoms like tension, fatigue and poor sleep
Social anxiety disorder — Intense fear of being judged, embarrassed or scrutinized in social or performance situations
Specific phobias — Marked fear of a specific object or situation — heights, flying, needles, animals — out of proportion to the danger
Agoraphobia and others — Fear of situations where escape or help might be hard to get; separation anxiety; other categories in the DSM-5-TR and ICD-11
This isn't a self-diagnosis checklist. Two people can both say "I have anxiety" and mean very different things. A qualified clinician is the one who can match your pattern to a diagnosis and rule out medical causes.
How are anxiety attacks treated?
The good news: panic attacks and panic disorder respond well to treatment, and you don't need to wait until things are "bad enough."
Cognitive behavioral therapy (CBT) comes first. The UK's NICE guideline recommends CBT for moderate to severe panic disorder, ideally 7 to 14 hours in total, usually as weekly sessions of one to two hours completed within four months (NICE). For milder cases, NICE suggests starting with self-help based on CBT principles. A Cochrane network meta-analysis of 54 trials with 3,021 patients found CBT, the most studied therapy, was often better than other psychological therapies, though the differences were small and the evidence was low quality (doi.org). Across 41 placebo-controlled trials in anxiety-related disorders, CBT had a moderate effect overall (g = 0.56), with smaller effects in panic disorder than in some other conditions (doi.org). NIMH calls CBT the "gold standard" psychotherapy for panic disorder (NIMH).
Antidepressants, mainly SSRIs, are the first-choice medication. NICE recommends antidepressants as the only medication for longer-term management of panic disorder, with SSRIs, SNRIs and tricyclic antidepressants having evidence behind them (NICE). A Cochrane review of 41 trials found that about seven people need to be treated with an antidepressant for one extra person to respond, compared with placebo, based on low-quality evidence (doi.org). These medicines usually take several weeks to work and can cause side effects early on, such as headaches, nausea or poor sleep (NIMH).
Benzodiazepines work fast but come with trade-offs. A Cochrane review of 24 trials found low-quality evidence that benzodiazepines beat placebo in the short term, but the trials didn't examine long-term effects or the risks of dependence and withdrawal (doi.org). NICE advises that they should not be prescribed for panic disorder because they are associated with worse long-term outcomes (NICE). If you already take one, don't stop suddenly — talk to your prescriber about a safe plan.
Lifestyle helps, but doesn't replace treatment. NICE recommends discussing exercise as part of good general health for everyone with panic disorder, and NIMH adds enough sleep, a healthy diet and support from people you trust (NICE) (NIMH).
For a full walkthrough of options, see panic treatment and anxiety treatment.
When to see a doctor or get emergency care
Call emergency services right away if you have:
chest pain, pressure or tightness, especially if it spreads to your arm, shoulder, neck, jaw, back or upper belly;
shortness of breath that doesn't ease as you slow your breathing, or blue lips;
fainting, a seizure, or confusion;
sudden weakness, numbness or drooping on one side of the body, or trouble speaking;
a very fast or irregular heartbeat that won't settle;
symptoms that feel different from your usual attacks, or a first-ever episode.
The 2021 US chest pain guideline stresses that "chest pain" includes pressure, tightness or discomfort in the chest, shoulders, arms, neck, back, upper abdomen or jaw, as well as shortness of breath and fatigue; that women more often have accompanying symptoms such as nausea and shortness of breath; and that people with acute chest pain should call emergency services rather than drive themselves (doi.org). Being told "it's probably anxiety" before a heart check is not good enough.
Make a regular appointment if:
you've had more than one panic attack, or you keep worrying about the next one;
you're avoiding places, driving, exercise or social plans because of attacks;
anxiety is disrupting sleep, work, school or relationships;
you're using alcohol, cannabis or sedatives to cope;
you also feel low, hopeless or numb most days.
If you have thoughts of harming yourself or ending your life, call or text 988 in the US, contact your local crisis line, or go to the nearest emergency department. In the emergency department chest pain study, 25% of people with panic disorder reported suicidal thoughts in the week before their visit, compared with 5% of those without it (doi.org). You deserve help for that as much as for the physical symptoms.
How to bring this up with your doctor — and what to ask for
Say it plainly. "I've had sudden attacks of a racing heart, breathlessness and terror, about twice a month since spring. They peak in a few minutes. I'm scared of the next one." That tells your doctor the pattern, the frequency and how much it's affecting you.
Bring context. When the attacks started, how long the peak lasts, whether they wake you at night, what tends to come before them (poor sleep, caffeine, stress, alcohol the night before), and any medications or supplements you take. If you track your heart rate, bring a few examples of what it did during an attack. A written log over a few weeks is far more useful than trying to remember on the spot.
Ask these specifically. Could anything physical be causing this — my heart rhythm, thyroid, blood sugar, a medication? Would an ECG or a longer heart rhythm monitor make sense? (In the PSVT study, an event monitor caught the rhythm problem in 47% of patients, compared with 9% for a 24-hour Holter monitor (doi.org).) Does this look like panic disorder, GAD, or something else? Can you refer me for CBT? If medication is an option, what are the side effects in the first few weeks, and how long before it works?
If you are dismissed. If you hear "it's just stress" before anything has been checked, try: "I understand anxiety is common, but I'd like to rule out a heart rhythm problem first. Can we note these symptoms in my record and decide on tests?" If your heart checks come back normal and you're still suffering, ask just as firmly for a referral to a therapist trained in CBT for panic. Both halves matter.
How Welltory helps
Welltory can't tell you whether you had a panic attack, and it can't diagnose anxiety or a heart condition. What it can do is make the physical side of anxiety visible, so you're working with a timeline instead of a blur.
Welltory tracks your stress load across the day, your heart rate variability (HRV) and resting heart rate, your sleep, and your morning energy, each compared with your own baseline rather than a population average. Over a few weeks you can see whether harder days line up with short nights, a run of high stress, or a drop in HRV — the same kinds of patterns the research links to anxiety. You can also take a short measurement before and after a few minutes of slow breathing and see how your body responds; a meta-analysis of 24 studies found HRV biofeedback — training with slow, paced breathing guided by your heart rhythm — was associated with a large reduction in self-reported stress and anxiety, though more well-controlled studies are needed (doi.org).
With My Patterns, you can tag moments like "panic attack," "woke up anxious," "two coffees" or "bad night," and over time see what tends to come before your harder days and what comes before the good ones. It won't replace a doctor or a therapist, but it gives you something concrete to bring to both — and it can help you notice progress as treatment starts to work.
How we made it
The clinical content rests on diagnostic criteria (American Psychiatric Association DSM-5-TR 2022), guidance from the US National Institute of Mental Health (NIMH) and the UK's National Institute for Health and Care Excellence (NICE CG113), large population surveys of panic attacks and anxiety disorders (Kessler et al. 2005, 2006; de Jonge et al. 2016), physiological and cognitive research on how panic unfolds (Meuret et al. 2011; Clark 1986; Chalmers et al. 2014), genetic studies (Hettema et al. 2001; Strom et al. 2026), research on triggers (Ben Simon et al. 2020; Vilarim et al. 2011; Craske & Tsao 2005), studies on chest pain, heart rhythm problems and heart risk (Fleet et al. 1996; Lessmeier et al. 1997; Tully et al. 2015; Gulati et al. 2021; Callaham 1989), breathing research (Zaccaro et al. 2018; Balban et al. 2023; Fincham et al. 2023; Schmidt et al. 2000; Meuret et al. 2008; Goessl et al. 2017), and systematic reviews of treatment (Pompoli et al. 2016; Carpenter et al. 2018; Bighelli et al. 2018; Breilmann et al. 2019). This article does not use Welltory user data. Drafted with AI tools, then edited, fact-checked, and medically reviewed by the Welltory team.


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This article is for educational purposes only and is not medical advice, diagnosis, or treatment. Only a qualified clinician can diagnose an anxiety disorder or recommend treatment. If you are in crisis or thinking about harming yourself, in the US call or text 988 (Suicide & Crisis Lifeline) right now, or go to your nearest emergency room.
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References
- American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision (DSM-5-TR). Washington, DC: American Psychiatric Association Publishing; 2022. https://doi.org/10.1176/appi.books.9780890425787
- National Institute of Mental Health. Panic disorder: when fear overwhelms. NIMH publication. https://www.nimh.nih.gov/health/publications/panic-disorder-when-fear-overwhelms
- National Institute for Health and Care Excellence. Generalised anxiety disorder and panic disorder in adults: management (CG113). 2011, updated 2020. https://www.nice.org.uk/guidance/cg113/chapter/Recommendations
- Kessler RC, Chiu WT, Jin R, Ruscio AM, Shear K, Walters EE. The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Archives of General Psychiatry 2006;63(4):415-424. https://doi.org/10.1001/archpsyc.63.4.415
- de Jonge P, Roest AM, Lim CC, et al. Cross-national epidemiology of panic disorder and panic attacks in the world mental health surveys. Depression and Anxiety 2016;33(12):1155-1177. https://doi.org/10.1002/da.22572
- Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters EE. Prevalence, severity, and comorbidity of 12-month DSM-IV disorders in the National Comorbidity Survey Replication. Archives of General Psychiatry 2005;62(6):617-627. https://doi.org/10.1001/archpsyc.62.6.617
- Meuret AE, Rosenfield D, Wilhelm FH, et al. Do unexpected panic attacks occur spontaneously? Biological Psychiatry 2011;70(10):985-991. https://doi.org/10.1016/j.biopsych.2011.05.027
- Clark DM. A cognitive approach to panic. Behaviour Research and Therapy 1986;24(4):461-470. https://doi.org/10.1016/0005-7967%2886%2990011-2
- Strom NI, Verhulst B, Bacanu SA, et al. Genome-wide association study of major anxiety disorders in 122,341 European-ancestry cases identifies 58 loci and highlights GABAergic signaling. Nature Genetics 2026;58(2):275-288. https://doi.org/10.1038/s41588-025-02485-8
- Chalmers JA, Quintana DS, Abbott MJ, Kemp AH. Anxiety disorders are associated with reduced heart rate variability: a meta-analysis. Frontiers in Psychiatry 2014;5:80. https://doi.org/10.3389/fpsyt.2014.00080
- Craske MG, Tsao JC. Assessment and treatment of nocturnal panic attacks. Sleep Medicine Reviews 2005;9(3):173-184. https://doi.org/10.1016/j.smrv.2004.11.003
- Fleet RP, Dupuis G, Marchand A, Burelle D, Arsenault A, Beitman BD. Panic disorder in emergency department chest pain patients: prevalence, comorbidity, suicidal ideation, and physician recognition. American Journal of Medicine 1996;101(4):371-380. https://doi.org/10.1016/S0002-9343%2896%2900224-0
- Lessmeier TJ, Gamperling D, Johnson-Liddon V, et al. Unrecognized paroxysmal supraventricular tachycardia: potential for misdiagnosis as panic disorder. Archives of Internal Medicine 1997;157(5):537-543. https://doi.org/10.1001/archinte.1997.00440260085013
- Tully PJ, Turnbull DA, Beltrame J, et al. Panic disorder and incident coronary heart disease: a systematic review and meta-regression in 1 131 612 persons and 58 111 cardiac events. Psychological Medicine 2015;45(14):2909-2920. https://doi.org/10.1017/S0033291715000963
- Callaham M. Hypoxic hazards of traditional paper bag rebreathing in hyperventilating patients. Annals of Emergency Medicine 1989;18(6):622-628. https://doi.org/10.1016/S0196-0644%2889%2980515-3
- Hettema JM, Neale MC, Kendler KS. A review and meta-analysis of the genetic epidemiology of anxiety disorders. American Journal of Psychiatry 2001;158(10):1568-1578. https://doi.org/10.1176/appi.ajp.158.10.1568
- Ben Simon E, Rossi A, Harvey AG, Walker MP. Overanxious and underslept. Nature Human Behaviour 2020;4(1):100-110. https://doi.org/10.1038/s41562-019-0754-8
- Vilarim MM, Rocha Araujo DM, Nardi AE. Caffeine challenge test and panic disorder: a systematic literature review. Expert Review of Neurotherapeutics 2011;11(8):1185-1195. https://doi.org/10.1586/ern.11.83
- Zaccaro A, Piarulli A, Laurino M, et al. How breath-control can change your life: a systematic review on psycho-physiological correlates of slow breathing. Frontiers in Human Neuroscience 2018;12:353. https://doi.org/10.3389/fnhum.2018.00353
- Balban MY, Neri E, Kogon MM, et al. Brief structured respiration practices enhance mood and reduce physiological arousal. Cell Reports Medicine 2023;4(1):100895. https://doi.org/10.1016/j.xcrm.2022.100895
- Fincham GW, Strauss C, Montero-Marin J, Cavanagh K. Effect of breathwork on stress and mental health: a meta-analysis of randomised-controlled trials. Scientific Reports 2023;13:432. https://doi.org/10.1038/s41598-022-27247-y
- Schmidt NB, Woolaway-Bickel K, Trakowski J, et al. Dismantling cognitive-behavioral treatment for panic disorder: questioning the utility of breathing retraining. Journal of Consulting and Clinical Psychology 2000;68(3):417-424. https://doi.org/10.1037/0022-006X.68.3.417
- Meuret AE, Wilhelm FH, Ritz T, Roth WT. Feedback of end-tidal pCO2 as a therapeutic approach for panic disorder. Journal of Psychiatric Research 2008;42(7):560-568. https://doi.org/10.1016/j.jpsychires.2007.06.005
- Pompoli A, Furukawa TA, Imai H, Tajika A, Efthimiou O, Salanti G. Psychological therapies for panic disorder with or without agoraphobia in adults: a network meta-analysis. Cochrane Database of Systematic Reviews 2016;(4):CD011004. https://doi.org/10.1002/14651858.CD011004.pub2
- Carpenter JK, Andrews LA, Witcraft SM, Powers MB, Smits JAJ, Hofmann SG. Cognitive behavioral therapy for anxiety and related disorders: a meta-analysis of randomized placebo-controlled trials. Depression and Anxiety 2018;35(6):502-514. https://doi.org/10.1002/da.22728
- Bighelli I, Castellazzi M, Cipriani A, et al. Antidepressants versus placebo for panic disorder in adults. Cochrane Database of Systematic Reviews 2018;(4):CD010676. https://doi.org/10.1002/14651858.CD010676.pub2
- Breilmann J, Girlanda F, Guaiana G, et al. Benzodiazepines versus placebo for panic disorder in adults. Cochrane Database of Systematic Reviews 2019;(3):CD010677. https://doi.org/10.1002/14651858.CD010677.pub2
- Gulati M, Levy PD, Mukherjee D, et al. 2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR guideline for the evaluation and diagnosis of chest pain. Circulation 2021;144(22):e368-e454. https://doi.org/10.1161/CIR.0000000000001029
- Goessl VC, Curtiss JE, Hofmann SG. The effect of heart rate variability biofeedback training on stress and anxiety: a meta-analysis. Psychological Medicine 2017;47(15):2578-2586. https://doi.org/10.1017/S0033291717001003


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