21 min read
5.0
8

Does masturbation make you tired? What happens after orgasm, and when it isn't normal

Brief drowsiness after orgasm is common; lasting flu-like symptoms or a sudden severe headache are not

Jane Smorodnikova
Founder & CEO
Tatsiana Yashyna
Deputy COO
Explains why many people feel tired after masturbating. Orgasm brings a short surge in heart rate, blood pressure and adrenaline that fades quickly, and prolactin rises and stays raised for over an hour; in a survey of 778 adults about half said it helped them sleep. Separates measured findings from hypotheses, covers 'masturbation fatigue', weakness and next-day tiredness, and describes post-orgasmic illness syndrome (POIS) from Waldinger's case series and recent reviews, with treatment left to a specialist. Covers when a headache at orgasm needs emergency care (ICHD-3), sleep needs, red flags, and how Welltory tags let you see your own pattern.

Short answer

Does masturbation make you tired? For many people, yes, a little, and briefly. Masturbation is a normal part of adult sexuality, and so is feeling drowsy afterwards. Orgasm comes with a short surge in heart rate, blood pressure and adrenaline that falls away quickly afterwards, and prolactin rises and stays raised for over an hour in both men and women (1, 2, 3). In one survey of 778 adults, about half said masturbation to orgasm helped them fall asleep or sleep better (4).

If you have wondered whether that heavy feeling means you are depleting something, you are not imagining the sensation, and it is not a moral failing or a sign of weakness. Research has found no drain on strength or performance from sexual activity the night before (5, 6). What deserves attention is the rare person who feels ill after nearly every orgasm, with flu-like symptoms that last days: that pattern has a name, post-orgasmic illness syndrome (POIS) (7, 8).

Note: this article explains what research says and is not medical advice. It cannot tell you what is happening in your body. Much of this research is small or self-reported, and we say so where it matters. If your questions are also about faith or values, those deserve their own conversation; this article covers health questions only. A sudden, severe headache during or after orgasm, an erection lasting four hours or more, or chest pain is an emergency: call 911.

Why do I feel tired after masturbating?

Most likely, your body is coming down from a short burst of arousal, often at the end of a day when you were already tired. No study has measured "tiredness after masturbation" directly, so this picture is assembled from laboratory work on what changes around orgasm.

Arousal is a small activation, and orgasm is its peak. In a German laboratory study of ten women, orgasm raised heart rate, blood pressure, adrenaline and noradrenaline; cortisol did not change (1). A matching study in ten men, sampling blood every two minutes, found adrenaline and noradrenaline rose during orgasm "with a rapid decline thereafter" (2). That quick rise and fall is the physical background to the heavy, settled feeling.

Prolactin goes up and stays up. The same group found prolactin rose substantially for more than an hour after orgasm, in men and women, from masturbation and from intercourse, but not after arousal without orgasm (3).

Timing does a lot of the work. If you masturbate in bed, late, after a long day, being drowsy at 11:30 p.m. is not a mystery.

What changes around orgasmWhat the research foundKeep in mind
Heart rate, blood pressure, adrenalineRise during orgasm and fall quickly afterwards (1, 2)Measured in laboratories with 10 participants per study
ProlactinRaised for over an hour after orgasm in men and women; unchanged after arousal without orgasm (3)Shows that prolactin rises, not that it makes you sleepy
OxytocinHigher during orgasm than at baseline in men and women (9)In the men's study with frequent sampling, the rise was not statistically consistent (2)
CortisolNo change after orgasm in women (1)One small study; do not read it as "orgasm lowers stress"

Does ejaculating make you tired?

Ejaculation can leave you drowsy for a while, and it is followed by a refractory period, when further erections and ejaculations are inhibited. Researchers know surprisingly little about either. A 2009 review described "the extremely limited evidence-based data" on the refractory period, noting that even the belief that it lengthens with age has no published supporting data (10).

Why do men get tired after ejaculation?

Probably several overlapping things. Men show the same sharp rise and fall in adrenaline and noradrenaline around orgasm and the same long prolactin rise as women (2, 3). One research group proposed that prolactin acts as a feedback signal that dampens sexual arousal after orgasm (3); the 2009 review argues that prolactin is not a major factor in the refractory period itself (10). Neither says prolactin is a sleeping pill. Add the hour, alcohol or a short night, and drowsiness has many possible contributors.

Why do men fall asleep after sex?

Research has not shown that men become sleepier after orgasm than women do. In a survey of 778 adults, men and women reported the same perceived effects of orgasm on falling asleep and sleep quality (4), and a diary study of 256 mostly student participants also found no gender differences (11). If one partner drifts off first, that is more likely about the individual and the hour than about being male. (See also: whether masturbation helps you sleep.)

Do women get tired after orgasm too?

Yes, the same changes are there. In the women's laboratory study, prolactin "substantially increased after orgasm" and was still raised 60 minutes later, alongside short-lived rises in heart rate, blood pressure and adrenaline (1). Oxytocin rose during orgasm in women as well as men (9). Post-orgasm sleepiness is often described as a male thing; the evidence does not support that framing (4). For the wider picture of how stress and sleep shape women's desire, see our article on women's libido, stress and sleep.

Prolactin and oxytocin: what the hormone research shows, and what it doesn't

Hormones are the usual explanation for tiredness after orgasm. The measurements are solid; the conclusions drawn from them often are not.

What is well established. Prolactin rises after orgasm in men and women and stays elevated for over an hour (3, 1). Oxytocin is higher during orgasm than at baseline in both sexes (9).

What is plausible but not proven. Researchers have suggested that the combined rise in oxytocin and prolactin after orgasm might make sleep easier (4). That is a hypothesis. No study has given people prolactin or oxytocin after orgasm and measured whether they fall asleep faster.

What is often overstated. An analysis pooling three laboratory studies found the prolactin rise after intercourse was about 400% greater than after masturbation, which the authors read as greater satiety (12). It compares a few small laboratory samples; it is not evidence that one kind of sex is healthier, and it says nothing about sleep.

One note on oxytocin. The 1987 study measured it in 9 men and 13 women (9); later work in men sampling blood every two minutes found a rise after orgasm that "did not reach statistical significance" (2). The human data are thinner than the "cuddle hormone" nickname suggests.

The takeaway: hormones may contribute to that relaxed feeling, but these studies cannot tell you that your tiredness is "your prolactin."

Does masturbation make you tired the next day?

No research shows that masturbation itself makes people tired the next day. When next-day tiredness happens, the more likely link is sleep: going to bed later. Here is what the sleep studies show:

  • Surveys. In an online survey of 778 adults, 54.1% of those who answered this question said masturbation with orgasm improved their sleep quality and 47.4% said it helped them fall asleep (4). This is self-report, from volunteers.

  • A two-week diary. Among 256 people who kept a sleep diary for 14 days, participants believed masturbation with orgasm helped their sleep, but in the diary data only partnered sex with orgasm was linked to falling asleep faster and better sleep quality; masturbation was not linked to any change (11).

  • A small study with sleep monitoring. Fourteen people in cohabiting couples wore a portable sleep-monitoring headband for 11 nights. After solo masturbation or partnered sex, they spent less time awake after falling asleep and slept more efficiently. They also went to bed "considerably later" (13). The authors flag the small sample and that all participants were healthy sleepers.

That last detail matters. If bedtime moves from 11 to 12:30 and your alarm is fixed, you lose sleep, whatever its quality. The American Academy of Sleep Medicine and Sleep Research Society recommend that adults sleep 7 or more hours a night on a regular basis (14); it is the lost hour, not the orgasm, that the evidence points to.

Next to that advice, a limit: tiredness that persists for weeks, whatever you change in the evening, is not something to put down to masturbation. Sleep disorders, sleep-related breathing disorders, depression and heavy stress are the most common causes of persistent fatigue in primary care (15); that is a reason to see a clinician.

Does masturbation make you weak?

No. There is no evidence that masturbation weakens muscles, drains strength or harms physical performance.

The belief that sex saps an athlete's strength goes back to ancient Greece and Rome. A 2016 systematic review found that "most studies generally seem to exclude a direct impact of sexual activity on athletic aerobic and strength performance," with a possible effect only when sex happens less than two hours before competition. It also noted that there were no studies at all on masturbation in this context (6). A small randomized study of eight adults found that intercourse to orgasm the night before had no effect on next-morning grip strength, jump height, push-ups, reaction time or work capacity (5).

How much energy is involved? In 21 young couples wearing armband sensors, partnered sex used about 101 kcal for men and 69 kcal for women, at moderate intensity, less than half of a 30-minute treadmill session (16). Masturbation has not been measured.

Testosterone is a separate question. In the men's laboratory study, testosterone did not change during arousal and orgasm (2). We cover the wider myths in testosterone after 40.

Masturbation fatigue: when frequency or feelings become the question

"Masturbation fatigue" is not a medical diagnosis. Online, the phrase is attached to claims that frequent masturbation causes exhaustion, brain fog or low motivation; we found no research supporting them. A few situations are worth a closer look.

When it is about control rather than frequency. There is no number of times that counts as "too much." "Porn addiction" and "masturbation addiction" are not diagnoses in the DSM-5. ICD-11, the World Health Organization's classification, includes compulsive sexual behaviour disorder (6C72): a persistent pattern of failing to control intense, repetitive sexual impulses or urges, over an extended period (for example, six months or more), that causes marked distress or significant impairment in daily life (17, 18). Distress that comes entirely from moral judgments or disapproval is not enough to meet the criteria (17). Feeling guilty is not a diagnosis.

When it is replacing sleep. If late nights regularly leave you with five hours, the tiredness is about the five hours.

When the low feeling is emotional, not physical. Some people feel sad, tearful, irritable or anxious after sex or orgasm, even when the experience was good. Researchers call this postcoital dysphoria. In an online survey of 230 female university students, 46% had experienced it at least once (19). In an international survey of 1,208 men, 41% had experienced it at some point and 3% to 4% said it happened regularly (20). Both were self-selected online samples about sexual activity in general, so treat the figures as rough.

Red flags that belong right here. If you feel unable to stop despite wanting to, if it is costing you work, relationships or sleep, or if distress is taking over, talk to a licensed therapist, ideally one who works with sexual health. If you have thoughts of harming yourself, call or text 988, the Suicide & Crisis Lifeline, available 24/7 (21).

What is post-orgasmic illness syndrome (POIS)?

Post-orgasmic illness syndrome (POIS) is a rare condition in which a person feels ill, not just tired, after nearly every ejaculation, for days. Dutch researchers Marcel Waldinger and Dave Schweitzer first described it in 2002 in two men with "severe fatigue, intense warmth, and a flulike state, with generalized myalgia" that lasted 4 to 7 days (7). The differences from ordinary drowsiness: POIS feels like sickness, happens almost every time, and lasts days rather than an hour.

What are the symptoms of post-orgasmic illness syndrome?

Waldinger proposed five preliminary criteria (8):

  1. One or more symptoms such as a flu-like feeling, extreme fatigue or exhaustion, muscle weakness, feverishness or sweating, mood changes or irritability, memory or concentration problems, incoherent speech, a congested or runny nose, or itchy eyes.

  2. Symptoms start within seconds, minutes or a few hours of ejaculation, whether from intercourse, masturbation or during sleep.

  3. They occur always or nearly always, in more than 90% of ejaculations.

  4. Most symptoms last about 2 to 7 days.

  5. They go away on their own.

In his study of 45 Dutch men suspected of having POIS, symptoms began within 30 minutes of ejaculation in 87%; 80% reported exhaustion, 87% concentration problems, and 78% a flu-like state (22). A 2025 review of 34 publications found fatigue (68.7%), poor concentration (63.9%) and irritation (51.9%) to be the commonest symptoms, with onset "usually within 45 min" and an average duration of 7 days (23).

What causes POIS?

Nobody knows for certain. In the 2011 study, 29 of 33 men (88%) who had skin-prick testing reacted to a diluted sample of their own semen, which led Waldinger to propose an allergic or autoimmune reaction to seminal fluid (22). Other hypotheses include an opioid-withdrawal-like effect, neuroendocrine changes and a temporary autonomic imbalance (24). All rest on small groups of patients.

Can women have POIS?

Rarely, and it is barely studied. Waldinger described POIS as occurring "although rarely" in women (8), and a 2025 systematic review of treatment studies found only two papers that included female patients (25). If flu-like symptoms reliably follow orgasm and last days, say so clearly to a clinician, whatever your sex.

How is POIS diagnosed and treated?

There is no blood test for POIS. Diagnosis rests on the pattern of symptoms, after considering look-alikes such as chronic prostatitis, headaches linked to orgasm and postcoital dysphoria; a 2019 review called POIS "a rare condition that is underdiagnosed" (24).

Treatment evidence is thin. A 2025 systematic review found 14 eligible studies, 12 of them case reports; most described medicines tried in individual patients, and a few described immune-based approaches, with no clear guidelines (25). It also cited a survey in which "Only 18% of sexual medicine experts report symptom improvement in more than 30% of the patients" (25). None of this is a recommendation: whether any treatment applies to you is a decision for a urologist or sexual medicine specialist who knows your history.

When tiredness after orgasm is a sign of something else

Most drowsiness after orgasm needs nothing. A few situations do.

A headache during or after orgasm. The International Headache Society recognizes a headache that builds with arousal and becomes intense at orgasm, but states that at first onset "it is mandatory to exclude subarachnoid haemorrhage," along with arterial dissection and reversible cerebral vasoconstriction syndrome (26). A sudden, severe headache during or after orgasm, especially the first time, is a 911 call, even if it starts to ease.

Pain, bleeding or injury. Genital, pelvic or testicular pain, bleeding, or an injury are not things to wait out. See a clinician, the same day if it is severe or sudden.

An erection that will not go away. The Urology Care Foundation advises: "If you have an erection that lasts for four (4) or more hours, go to the emergency room for treatment" (27). Whatever caused it, that is an ER or 911 situation.

New erection problems. Erectile dysfunction is associated with a higher risk of cardiovascular events and death from any cause, and a large meta-analysis found that risk was relatively higher in younger men (28). New difficulty getting or keeping an erection is a reason to see a doctor, partly for your heart. We explain why in your sex life as a vital sign.

Tiredness that is everywhere. If you are exhausted most of the day, the question is not about masturbation. Sleep disorders, sleep-related breathing problems, depression and heavy stress are the most common causes of persistent fatigue in primary care (15); a doctor's appointment is a better next step than cutting back.

Living with tiredness after orgasm: the questions people ask next

Is it normal to feel tired after masturbating?

Yes. Feeling relaxed or drowsy after masturbating to orgasm is common and consistent with what laboratory research shows: a short rise in heart rate and adrenaline that falls quickly, and a prolactin increase that lasts over an hour in both men and women (2, 3). In a survey of 778 adults, around half said masturbation to orgasm improved their sleep (4). What is not typical is feeling sick, feverish or foggy for days after nearly every orgasm; that pattern fits post-orgasmic illness syndrome and is worth raising with a clinician (8).

How do I not feel tired after ejaculation?

There is no research on preventing ordinary tiredness after ejaculation, because it is not considered a problem. A practical approach is to look at timing: if you need to be alert afterwards, the hour matters more than the act. Alcohol and a short night make any drowsiness heavier. If tiredness after ejaculation is severe, lasts days or feels like illness, that is not something to manage with tips; it is a reason to see a urologist or sexual medicine specialist about post-orgasmic illness syndrome (8).

Should I avoid masturbating before a workout, game or race?

The evidence does not support abstaining. A systematic review concluded that sexual activity the day before competition does not appear to harm performance, with a possible negative effect only when it happens less than two hours beforehand (6). In a small randomized study, intercourse to orgasm the night before did not change strength, power, endurance or reaction time the next morning (5). No studies have looked at masturbation and sport specifically (6), so treat this as reassuring rather than proven; protecting your sleep the night before matters more (14).

Will masturbating at night make me groggy at work the next morning?

Masturbation itself has not been shown to cause next-day grogginess. The more likely link is sleep. In a small study using home sleep monitoring, people went to bed considerably later on nights with masturbation or partnered sex, even though their sleep was more efficient once they were asleep (13). If you are regularly short of the 7 or more hours adults are advised to get (14), the lost time is the likely reason for morning fog. If you are getting enough sleep and are still exhausted, see a clinician, because persistent fatigue has more common causes worth checking (15).

Why do I feel sad or anxious after masturbating?

Feeling low, tearful, irritable or anxious after sexual activity has a name, postcoital dysphoria, and it is not rare: 46% of women in one university sample and 41% of men in an international online sample had experienced it at least once (19, 20). These studies covered sexual activity in general, and the samples were self-selected. If guilt shaped by upbringing or values is part of it, that is worth naming too. An occasional episode is not, on its own, a sign that something is wrong. If it happens most of the time, comes with depression, or feels unmanageable, a licensed therapist can help. If you have thoughts of self-harm, call or text 988 (21).

My partner falls asleep right after sex and I don't. Is something wrong?

Probably not. In a survey of 778 adults, men and women reported the same perceived effects of orgasm on falling asleep, and a two-week diary study also found no gender differences (4, 11). In the diary study, it was partnered sex with orgasm that was linked to falling asleep faster (11), so whether both partners reached orgasm may matter. If mismatched timing has become a source of tension, it is a conversation to have, not a symptom. Our article on responsive desire in long relationships covers how desire and closeness shift over time.

How to bring this up with your doctor

Talking about masturbation with a clinician can feel awkward. These are ordinary medical questions, and you can keep the language clinical.

Choose who to see. For ordinary tiredness that worries you, a primary care doctor is a good start. For symptoms that look like POIS, a urologist or a sexual medicine specialist is more likely to have seen it; women can start with a gynecologist. For distress, compulsive patterns or low mood after sex, a licensed therapist is the right fit.

Say it in one sentence. For example: "After I ejaculate, through sex or on my own, I feel like I have the flu for about four days, and it happens almost every time." That covers the trigger, the symptoms, the timing and the frequency, which are the things the POIS criteria ask about (8).

Bring a short written record. Dates, when symptoms started, what they were, how long they lasted, and anything else going on (alcohol, illness, a short night). Two or three weeks of notes beat memory.

Ask useful questions. "Could this be post-orgasmic illness syndrome, and what else should we rule out?" "Is there anyone you would refer me to?" "Do any of my medications affect this?"

Do not wait for an appointment for these. A sudden severe headache during or after orgasm, chest pain or fainting is a 911 call (26). An erection lasting four hours or more needs the emergency room (27). Pain, bleeding or injury needs a clinician promptly. New erection problems deserve a doctor's visit, partly for your heart (28). Thoughts of self-harm: call or text 988 (21).

Start understanding your body

Learn what affects your energy, stress, sleep, and daily state. Get the app.

How Welltory helps — and what it cannot do

The limits first. Welltory is a general wellness product, not a medical device. It does not diagnose, detect, predict, monitor, prevent, treat or mitigate post-orgasmic illness syndrome, fatigue, sleep disorders, erectile problems or any other condition, and it cannot tell you anything about your hormones. It makes no promise that anything you do will lower your stress or improve your sleep. What it offers is a consistent record, with your notes beside it.

You note the evening; the app is already recording. When Welltory marks a stress stretch and asks "What happened?", or a rest stretch and asks "What helped you rest?", you can tap a suggested tag, type a few words, or just talk. For something this private, you may prefer a neutral label you will recognize, such as "me time", next to other things that shape an evening: "late night", "glass of wine", "screens in bed", "argument". You can also add a note any time with the plus icon ("Share your thoughts…"); it goes into your Journal.

Then look at the night and the next day. Stress minutes, sleep analysis, resting heart rate, HRV and Battery were recorded the same way as every day. With your tag beside them, you can see whether late evenings line up with shorter sleep or a lower Battery next morning, against your own history, not a population average or a line marked normal. Stress minutes, sleep analysis and Battery need a supported wearable.

After a few weeks, My Patterns has something to work with. My Patterns collects the tags you add to stress and rest stretches, so it needs iOS with an Apple Watch or Oura. Patterns start to become visible at around seven tagged events, and insights typically need a tag about seven times in the current month plus some history from the month before. It shows which tagged situations tend to come alongside stress or rest, which rare tags your body responded to strongly, trends by day of week, heart-rate data, and every time a tag occurred.

If you suspect POIS, that list becomes a timeline for the appointment. Notes such as "flu-like day 2" or "brain fog" in your Journal (Premium), next to dates, are the kind of record the POIS criteria ask about. From the Welltory web app you can export a CSV (Dashboard → choose a chart → Export). It is a record you made, not a conclusion the app reached; any pattern in it is an association to discuss with a doctor, not proof of a cause.

The red flags belong here too, in the same type size: a sudden severe headache during or after orgasm, chest pain or fainting means 911; an erection lasting four hours or more means the emergency room; pain, bleeding or injury means a clinician; new erection problems mean a doctor's visit; distress or a sense of losing control means a licensed therapist; thoughts of self-harm mean calling or texting 988 (26, 27, 28, 21). None of these is a reason to add a tag and wait.

Where to find other people in the same situation. If you are also living with an energy-limiting condition, Welltory runs a paid, moderated community called Energy Lab for women aged 18 to 65 living with ME/CFS, long COVID, fibromyalgia, POTS, MCAS and similar. It runs alongside the app: you keep collecting your own data, and the Lab is where people learn to read it together, with a medical board answering the science. It is education and peer support, not medical care, it does not replace your clinician, and there is a 14-day money-back guarantee on a first purchase.

How we made it

Made with AI tools, then edited and fact-checked by the Welltory team. See our Editorial & AI policy.

Data analysis by Jane Smorodnikova, co-founder of Welltory and the person who built the methodology behind how we read physiological data.

Written by Tatsiana Yashyna.

Discounts for blog readers: up to 36% off

See what affects your energy, stress, sleep, and daily state with Welltory

This article is for educational purposes only and is not medical advice. A sudden, severe headache during or after orgasm needs emergency care: call 911. Pain, bleeding or injury needs a clinician; an erection lasting more than four hours means the ER or 911. If you have thoughts of harming yourself, call or text 988. Welltory is a general wellness product and does not diagnose, detect or predict any condition.

Was this helpful?

Ask AI for a summary of page

ChatGPTGeminiClaudePerplexityGrok

Written by Jane Smorodnikova

The founder and CEO of Welltory. A recognized tech leader with two Master's degrees and experience at MIT, she has scaled Welltory to over 17 million users.

Written by Tatsiana Yashyna

Deputy COO at Welltory. With a background in medicine and years of working with health data, she translates research and real physiological signals — sleep, stress, heart rate, and hormones — into clear, evidence-based explanations that help people understand what their bodies are telling them.

References

  1. Exton MS, Bindert A, Krüger T, Scheller F, Hartmann U, Schedlowski M. Cardiovascular and endocrine alterations after masturbation-induced orgasm in women. Psychosomatic Medicine 1999;61(3):280–289. https://doi.org/10.1097/00006842-199905000-00005
  2. Krüger TH, Haake P, Chereath D, Knapp W, Janssen OE, Exton MS, Schedlowski M, Hartmann U. Specificity of the neuroendocrine response to orgasm during sexual arousal in men. Journal of Endocrinology 2003;177(1):57–64. https://doi.org/10.1677/joe.0.1770057
  3. Krüger TH, Haake P, Hartmann U, Schedlowski M, Exton MS. Orgasm-induced prolactin secretion: feedback control of sexual drive? Neuroscience & Biobehavioral Reviews 2002;26(1):31–44. https://doi.org/10.1016/s0149-7634%2801%2900036-7
  4. Lastella M, O'Mullan C, Paterson JL, Reynolds AC. Sex and sleep: perceptions of sex as a sleep promoting behavior in the general adult population. Frontiers in Public Health 2019;7:33. https://doi.org/10.3389/fpubh.2019.00033
  5. Zavorsky GS, Vouyoukas E, Pfaus JG. Sexual activity the night before exercise does not affect various measures of physical exercise performance. Sexual Medicine 2019;7(2):235–240. https://doi.org/10.1016/j.esxm.2018.12.002
  6. Stefani L, Galanti G, Padulo J, Bragazzi NL, Maffulli N. Sexual activity before sports competition: a systematic review. Frontiers in Physiology 2016;7:246. https://doi.org/10.3389/fphys.2016.00246
  7. Waldinger MD, Schweitzer DH. Postorgasmic illness syndrome: two cases. Journal of Sex & Marital Therapy 2002;28(3):251–255. https://doi.org/10.1080/009262302760328280
  8. Waldinger MD. Post orgasmic illness syndrome (POIS). Translational Andrology and Urology 2016;5(4):602–606. https://doi.org/10.21037/tau.2016.07.01
  9. Carmichael MS, Humbert R, Dixen J, Palmisano G, Greenleaf W, Davidson JM. Plasma oxytocin increases in the human sexual response. The Journal of Clinical Endocrinology & Metabolism 1987;64(1):27–31. https://doi.org/10.1210/jcem-64-1-27
  10. Levin RJ. Revisiting post-ejaculation refractory time—what we know and what we do not know in males and in females. The Journal of Sexual Medicine 2009;6(9):2376–2389. https://doi.org/10.1111/j.1743-6109.2009.01350.x
  11. Oesterling CF, Borg C, Juhola E, Lancel M. The influence of sexual activity on sleep: a diary study. Journal of Sleep Research 2023;32(4):e13814. https://doi.org/10.1111/jsr.13814
  12. Brody S, Krüger TH. The post-orgasmic prolactin increase following intercourse is greater than following masturbation and suggests greater satiety. Biological Psychology 2006;71(3):312–315. https://doi.org/10.1016/j.biopsycho.2005.06.008
  13. Lastella M, Miller DJ, Montero A, Sprajcer M, Ferguson SA, Browne M, Vincent GE. Sleep on it: a pilot study exploring the impact of sexual activity on sleep outcomes in cohabiting couples. Sleep Health 2025;11(2):198–205. https://doi.org/10.1016/j.sleh.2024.11.004
  14. Watson NF, Badr MS, Belenky G, et al. Recommended amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society. Journal of Clinical Sleep Medicine 2015;11(6):591–592. https://doi.org/10.5664/jcsm.4758
  15. Maisel P, Baum E, Donner-Banzhoff N. Fatigue as the chief complaint—epidemiology, causes, diagnosis, and treatment. Deutsches Ärzteblatt International 2021;118:566–576. https://doi.org/10.3238/arztebl.m2021.0192
  16. Frappier J, Toupin I, Levy JJ, Aubertin-Leheudre M, Karelis AD. Energy expenditure during sexual activity in young healthy couples. PLoS ONE 2013;8(10):e79342. https://doi.org/10.1371/journal.pone.0079342
  17. World Health Organization. ICD-11 for Mortality and Morbidity Statistics: 6C72 Compulsive sexual behaviour disorder. https://icd.who.int/browse/2024-01/mms/en#1630268048
  18. Kraus SW, Krueger RB, Briken P, First MB, Stein DJ, Kaplan MS, et al. Compulsive sexual behaviour disorder in the ICD-11. World Psychiatry 2018;17(1):109–110. https://doi.org/10.1002/wps.20499
  19. Schweitzer RD, O'Brien J, Burri A. Postcoital dysphoria: prevalence and psychological correlates. Sexual Medicine 2015;3(4):235–243. https://doi.org/10.1002/sm2.74
  20. Maczkowiack J, Schweitzer RD. Postcoital dysphoria: prevalence and correlates among males. Journal of Sex & Marital Therapy 2019;45(2):128–140. https://doi.org/10.1080/0092623x.2018.1488326
  21. 988 Suicide & Crisis Lifeline. https://988lifeline.org/
  22. Waldinger MD, Meinardi MM, Zwinderman AH, Schweitzer DH. Postorgasmic illness syndrome (POIS) in 45 Dutch Caucasian males: clinical characteristics and evidence for an immunogenic pathogenesis (Part 1). The Journal of Sexual Medicine 2011;8(4):1164–1170. https://doi.org/10.1111/j.1743-6109.2010.02166.x
  23. Odusanya BO, Pearce I, Modgil V. Post orgasmic illness syndrome: a review. International Journal of Impotence Research 2025;37(6):422–425 (published online 2024). https://doi.org/10.1038/s41443-024-00860-3
  24. Abdessater M, Elias S, Mikhael E, Alhammadi A, Beley S. Post orgasmic illness syndrome: what do we know till now? Basic and Clinical Andrology 2019;29:13. https://doi.org/10.1186/s12610-019-0093-7
  25. Ponce S, Chapalamadugu M, Levine S, Stokes C, Radillo K, Johnson O, et al. Treatments for postorgasmic illness syndrome: a systematic review. The Journal of Sexual Medicine 2025;22(7):1236–1243. https://doi.org/10.1093/jsxmed/qdaf112
  26. Headache Classification Committee of the International Headache Society. ICHD-3, 4.3 Primary headache associated with sexual activity. https://ichd-3.org/other-primary-headache-disorders/4-3-primary-headache-associated-with-sexual-activity/
  27. Urology Care Foundation (American Urological Association). Priapism. https://www.urologyhealth.org/urology-a-z/p/priapism
  28. Vlachopoulos CV, Terentes-Printzios DG, Ioakeimidis NK, Aznaouridis KA, Stefanadis CI. Prediction of cardiovascular events and all-cause mortality with erectile dysfunction: a systematic review and meta-analysis of cohort studies. Circulation: Cardiovascular Quality and Outcomes 2013;6(1):99–109. https://doi.org/10.1161/circoutcomes.112.966903

FAQ